REVISTA CHILENA DE ENFERMEDADES RESPIRATORIAS

41 / 66

117
22.- Collard HR, Richeldi L, Kim DS, Tanigu-
chi H, Tschoepe I, Luisetti M, et al. Acute
exacerbations in the INPULSIS trials of nintedanib in
idiopathic pulmonary fibrosis. Eur Respir J 2017; 49 (5)
pii: 1601339. doi 10.1183/13993003.01339-2016.
23.- Raghu G, Crestani B, Bailes Z, et al. Effect
of anti-acid medication on reduction in FVC decline
with nintedanib. Eur Respir J 2015; 46 (Suppl 59):
OA4502.
24.- Kreuter M, Wuyts W, Renzoni E,
et al. Antiacid therapy and
disease outcomes in idiopathic pulmonary fibrosis: a
pooled analysis. Lancet Respir Med 2016; 4: 381-9
25.- European Medicines Agency. Esbriet pro-
duct information.
document_library/EPAR_Poduct_Information/hu-
man/002154/WC500103049.pdf. (Date last accessed:
march 12, 2018).
26.- Raghu G, Meyer KC. Silent gastrooesophageal
reflux and microaspiration in IPF: mounting evidence
for anti-reflux therapy? Eur Respir J 2012; 39: 242-5.
27.- Raghu G, Morrow E, Collins BF,
et al. Laparoscopic
anti-reflux surgery for idiopathic pulmonary fibrosis at
a single centre. Eur Respir J 2016; 48: 826-32.
28.- Ghebre YT, Raghu G. Idiopathic Pulmonary Fi-
brosis: Novel concepts of proton pump inhibitors as
antifibrotic drug. Am J Respir Crit Care Med 2016; 193:
1345-52.
29.- Yoshida N, Yoshikawa T, TanakaY, Fujita
N, Kassai K, Naito Y, et al. A new mechanism
for anti-inflammatory actions of proton pump inhibi-
tors–inhibitory effects on neutrophil-endothelial cell
interactions. Aliment Pharmacol Ther 2000; 14 (Suppl
1): 74-81.
30.- Kedika RR, Souza RF, Spechler SJ. Potential
anti-inflammatory effects of proton pump inhibitors: a
review and discussion of the clinical implications. Dig
Dis Sci 2009; 54: 2312-7.
31.- Ghebremariam YT, Cooke JP, Gerhart W,
Griego C, Brower JB, Doyle-Eisele M, et al.
Pleiotropic effect of the proton pump inhibitor esome-
prazole leading to suppression of lung inflammation and
fibrosis. J Transl Med 2015; 13: 249.
32.- Pilot Trial Of Omeprazole in
Idiopathic Pulmonary Fibrosis (IPF) (PPIPF). https://
clinicaltrials.gov/ct2/ show/NCT02085018. Date last
accessed: October 11, 2017. Clinical Trials identifier:
NCT02085018.
33.- . Treatment of IPF with lapa-
roscopic anti-reflux surgery (WRAP-IPF). https://
clinicaltrials.gov/ct2/ show/NCT01982968. Date last
accessed: October 11, 2017. Clinical Trials identifier:
NCT01982968.
Correspondencia a:
Dr. Fernando Tirapegui Sanhueza
Departamento de Enfermedades Respiratorias, Facultad
de Medicina, Pontificia Universidad Católica de Chile.
Diagonal Paraguay 362, Sexto Piso, Santiago, Chile.
Email:
Aspiración y fibrosis pulmonar idiopática
Rev Chil Enferm Respir 2017; 33: 111-117