NEUMOLOGÍA PEDIÁTRICA

C o n t e n i d o d i s p o n i b l e e n h t t p : / / www. n e umo l o g i a - p e d i a t r i c a . cl 130 Neumol Pediatr 2019; 14 (3): 126 - 130 Relación del reflujo gastroesofágico y manifestaciones respiratorias en las manifestaciones extraesofágicas como la tos crónica y el asma mal controlada, con una respuesta muy similar a placebo. CONCLUSIONES La enfermedad por reflujo gastroesofágico es una patología frecuente en la población pediátrica, que ocasionalmente puede tener manifestaciones extra digestivas. Frecuentemente los síntomas respiratorios y particularmente los laringeos son sobre-atribuidos a ERGE, y los resultados del tratamiento actual con IBP no son óptimos. No se recomienda el tratamiento empírico de reflujo en pacientes con síntomas extraesofágicos atribuidos a esta patología, sin evidencia clínica o de exámenes de ERGE. Conflictos de interés Declaro no tener conflictos de interés. REFERENCIAS 1. Rosen R, Vandenplas Y, Singendonk M, Cabana M, DiLorenzo C, Gottrand F, et al. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2018;66(3):516-54. 2. Singendonk M, Goudswaard E, Langendam M, van Wijk M, van Etten-Jamaludin F, Benninga M, et al. Prevalence of Gastroesophageal Reflux Disease Symptoms in Infants and Children. Journal of Pediatric Gastroenterology and Nutrition. 2019;68(6):811-7. 3. Benninga MA, Faure C, Hyman PE, St James Roberts I, Schechter NL, Nurko S. Childhood Functional Gastrointestinal Disorders: Neonate/Toddler. Gastroenterology. 2016;130:1519-26. 4. Aziz Q, Fass R, Gyawali CP, Miwa H, Pandolfino JE, Zerbib F. Functional Esophageal Disorders. Gastroenterology. 2016;150:1369-79. 5. Broers C, Tack J, Pauwels A. Review article: gastro- oesophageal reflux disease in asthma and chronic obstructive pulmonary disease. Aliment Pharmacol Ther. 2018;47(2):176-91. 6. Saleh CM, Smout AJ, Bredenoord AJ. The diagnosis of gastro-esophageal reflux disease cannot be made with barium esophagograms. Neurogastroenterol Motil. 2015;27(2):195-200. 7. Macharia EW. Comparison of upper gastrointestinal contrast studies and pH/impedance tests for the diagnosis of childhood gastro-oesophageal reflux. Pediatr Radiol. 2012;42(8):946-51. 8. Yang J, Codreanu I, Servaes S, Zhuang H. Radionuclide Salivagram and Gastroesophageal Reflux Scintigraphy in Pediatric Patients: Targeting Different Types of Pulmonary Aspiration. Clin Nucl Med. 2015;40(7):559- 63. 9. Woodland P, Singendonk MMJ, Ooi J, Nikaki K, Wong T, Lee C, et al. Measurement of Salivary Pepsin to Detect Gastroesophageal Reflux Disease Is Not Ready for Clinical Application. Clin Gastroenterol Hepatol. 2019;17(3):563-5. 10. Kahrilas PJ, Kia L. Pepsin: A Silent Biomarker for Reflux Aspiration or an Active Player in Extra-Esophageal Mucosal Injury? Chest. 2015;148(2):300-1. 11. Kelly EA, Parakininkas DE, Werlin SL, Southern JF, Johnston N, Kerschner JE. Prevalence of pediatric aspiration-associated extraesophageal reflux disease. JAMA Otolaryngol Head Neck Surg. 2013;139(10):996- 1001. 12. Doshi A, Bernard-Stover L, Kuelbs C, Castillo E, Stucky E. Apparent Life-Threatening Event Admisions and Gastroesophageal Reflux Disease. Pediatr Emer Care. 2012;28:17-21. 13. Singendonk MMJ, Jaime F, Salvatore S, Tabbers MM, Benninga MA, Vandenplas Y. Multichannel Intraluminal Impedance and pH Monitoring (pH-MII) in Infants and Children. Gastroesophageal Reflux in Children2017. p. 89-110. 14. Hicks DM, Ours TM, Abelson TI, Vaezi MF, Richter JE. The Prevalence of Hypopharynx Findings Associated with Gastroesophageal Reflux in Normal Volunteers. Journal of Voice. 2002;16(4):564-79. 15. Belafsky P, Postma N, Koufman J. The Validity and Reliability of the Reflux Finding Score (RFS). The Laryngoscope. 2001;111:1313-7. 16. Rosen R, Mitchell PD, Amirault J, Amin M, Watters K, Rahbar R. The Edematous and Erythematous Airway Does Not Denote Pathologic Gastroesophageal Reflux. J Pediatr. 2017;183:127-31. 17. Zerbib F, Dulery C. Facts and Fantasies on Extraesophageal Reflux: A Gastroenterologist Perspective. J Clin Gastroenterol. 2017;51(9):769-76. 18. De Bruyne P, Ito S. Toxicity of long-term use of proton pump inhibitors in children. Arch Dis Child. 2018;103(1):78-82. 19. Blondeau K, Mertens V, Dupont L, Pauwels A, Farre R, Malfroot A, et al. The relationship between gastroesophageal reflux and cough in children with chronic unexplained cough using combined impedance- pH-manometry recordings. Pediatr Pulmonol. 2011;46(3):286-94. 20. Chang AB, Oppenheimer JJ, Kahrilas PJ, Kantar A, Rubin BK, Weinberger M, et al. Chronic Cough and Gastroesophageal Reflux in Children: CHEST Guideline and Expert Panel Report. Chest. 2019;156(1):131-40. 21. Blake K, Teague WG. Gastroesophageal reflux disease and childhood asthma. Curr Opin Pulm Med. 2013;19(1):24-9. 22. Ambartsumyan L, Nurko S, Rosen R. Gastrointestinal Dysmotility and the Implications for Respiratory Disease. Curr Treat Options Pediatr. 2019;5(2):197-214. 23. Davidson G, Wenzl TG, Thomson M, Omari T, Barker P, Lundborg P, et al. Efficacy and safety of once-daily esomeprazole for the treatment of gastroesophageal reflux disease in neonatal patients. J Pediatr. 2013;163(3):692-8 e1-2.